HIGHLIGHTED TOPIC Hypoxia HIF and pulmonary vascular responses to hypoxia
نویسندگان
چکیده
Shimoda LA, Laurie SS. Hif and pulmonary vascular responses to hypoxia. J Appl Physiol 116: 867– 874, 2014. First published December 12, 2013; doi:10.1152/japplphysiol.00643.2013.—In the lung, acute reductions in oxygen lead to hypoxic pulmonary vasoconstriction, whereas prolonged exposures to hypoxia result in sustained vasoconstriction, pulmonary vascular remodeling, and the development of pulmonary hypertension. Data from both human subjects and animal models implicate a role for hypoxia-inducible factors (HIFs), oxygen-sensitive transcription factors, in pulmonary vascular responses to both acute and chronic hypoxia. In this review, we discuss work from our laboratory and others supporting a role for HIF in modulating hypoxic pulmonary vasoconstriction and mediating hypoxia-induced pulmonary hypertension, identify some of the downstream targets of HIF, and assess the potential to pharmacologically target the HIF system.
منابع مشابه
Invited Review HIGHLIGHTED TOPIC Oxygen Sensing in Health and Disease O2-regulated gene expression: transcriptional control of cardiorespiratory physiology by HIF-1
Semenza, Gregg L. O2-regulated gene expression: transcriptional control of cardiorespiratory physiology by HIF-1. J Appl Physiol 96: 1173–1177, 2004; 10.1152/japplphysiol.00770.2003.—The cardiovascular and respiratory systems play key roles in O2 homeostasis. Physiological responses to hypoxia involve changes in gene expression that are mediated by the transcriptional activator hypoxia-inducibl...
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